Key Concepts: a) Complement system, specially trough C5a, participate during the process of inflammation.
b) C5a is a chemoattractant molecule: Recruit cells to the site of the infection. Activates macrophages.
c) Complement participates in sepsis
d) Some complement proteins (e.g. MBL) are considered acute phase proteins. IL-6 plays a fundamental role in increasing acute phase protein production.
Table of Contents:
00:00 - Role of the complement system in inflammation
02:51 - C5a is a chemoattractant
03:47 - C5a activates macrophages and promotes phagocytosis
04:44 - C5a activates mast cells
05:25 - IL-6 induces acute phase protein production
06:07 - C5a participates in sepsis, role of PAMPs (LTA, LPS) and PRRs (TLR2, TLR4)
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